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KMID : 0829220120360050293
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Korean Journal of Oral and Maxillofacial Pathology
2012 Volume.36 No. 5 p.293 ~ p.300
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Protective Mechanisms of PF2401-SF, Standardized Fraction of Salvia miltiorrhiza, Against Carbon Tetrachloride-induced Hepatotoxicity
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Kim Woong-Hyun
Sohn Dong-Hwan
Lee Sung-Hee
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Abstract
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We previously prepared a standardized and purified extract of Salvia miltiorrhiza, PF2401-SF, and showed that it protected
against hepatic injury more effectively than ethanol based extraction. In this study, we determined the hepatoprotective mechanisms of PF2401-SF in vivo. Hepatic injury was induced in mice by using carbon tetrachloride (CCl4). Treatment with PF2401-SF (1 or 10 mg/kg, p.o.) significantly reduced the levels of alanine transaminase (ALT) and aspartate transaminase (AST) in the plasma. PF2401-SF treatment resulted in further elevation of the CCl4-induced heme oxygenase-1 (HO-1) expression, which contributed to the PF2401-SF-mediated liver protection. Additionally, PF2401-SF treatment significantly reduced the c-Jun NH2-terminal kinase (JNK) phosphorylation induced by CCl4. Taken together, these results suggest that the protective effect of PF2401-SF, a standardized fraction of S. miltiorrhiza, against CCl4-induced hepatic injury in mice arises from its induction effect on HO-1 and inhibitory effect on JNK phosphorylation.
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KEYWORD
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PF2401-SF, Heme oxygenase-1, c-Jun NH2-terminal kinase, Salvia miltiorrhiza, Hepatoprotection, Carbon tetrachloride
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